spContent=Medical Immunology is an independent medical basic course for bioscience particularly for medical students, major in clinical medicine, ophthalmology, pediatrics, obstetrics and gynecology, medical imaging, anesthesiology or preventive medicine.
Medical Immunology is an independent medical basic course for bioscience particularly for medical students, major in clinical medicine, ophthalmology, pediatrics, obstetrics and gynecology, medical imaging, anesthesiology or preventive medicine.
—— 课程团队
课程概述
Medical Immunology plays a major role in both basic research and clinical application of medical science. This course mainly introduces the components and basic functions of immune system, and knowledge about clinical immunological diseases, principle of immune prevention and treatment.
According to the COVD-19 pandemic, Immunology not only provided explanation of basic pathogenic mechanism of the virus but also provided prevention and treatment strategy, especially the development of vaccine.
授课目标
1. Students are required to describe the main components of immune system and their functions, and how the immune system recognizes and responses to antigens.
2. Students are required to understand mechanisms of the pathological immune responses (hypersensitivity) and its common diseases, immunodiagnosis and immunoprevention.
课程大纲
Introduction of Immunology
课时目标：1.Master the concept of immunity and the functions of immune system, the composition of immune organs.2.Be familiar with the types and properties of immunity.3. Understand the brief history of immunology.
1.1 Introduction of Immunity,the composition and functions of immune system.
1.2 Brief history of immunology
Antigen
课时目标：1. Master the concept of antigen and its properties (immunogenicity and antigenicity);Master the characteristics of TD-Ag and TI-Ag;2.Be familiar with the factors required for immunogenicity of antigen, the concept of superantigen and adjuvant, the types of mitogen;3.Understand the mechanism of superantigen action, the types of adjuvant and the mechanism of its action.
2.1 Definition of antigen, hapten,eptope
2.2 Specificity and Cross-Reaction of Antigens
2.3 Factors Affecting Immunogenicity
2.4 Classification of Antigens
Immunoglobulin and antibody（Ab）
课时目标：1. Master the concept, the structure, the hydrolyzed fragments and the function of Ig and antibody;2. Be familiar with the characteristics and functions of the five classes of Ig, the multiclonal antibody, monoclonal antibody and engineered antibody; 3. Understand diversity of immunoglobulin gene and Ab.
3.1 Definition of Immunoglobulin & Antibody
3.2 Structure and Biological Function of Immunoglobulin
3.3 Biological characteristics of different antibodies
3.4 Technology of Antibody
Complement System
课时目标：1. Master the concept; know the physicochemical property and components of complement system;2. Master the pathways of complement activation (the classical pathway, the MBL pathway and the alternative pathway) and its function;3. understand the diseases association with complement.
4.1 Definitions and properties of complement system
4.2 Activation pathways of complement system
4.3 Biological functions of complement
4.4 Regulation of complement system and disease related with complement system
Cytokine
课时目标：1. Master the concept, common characteristics and biological functions of cytokine;2. Understand cytokines receptors, clinical application of cytokines.
5.1 Definition and general properties of cytokines
5.2 Classification of cytokines
5.3 Biological functions of cytokines
5.4 Cytokine and disease
Major Histocompatibility complex (MHC)
课时目标：1.Master the concept of MHC and HLA, the classical genes and the characteristics(structure, distribution and function) of HLA-Ⅰand Ⅱ molecules;2.Master MHC polymorphism; 3. Understand the interaction between HLA molecule and peptide,clinical application of HLA;
6.1 Composition of HLA complex
6.2 Genetic characteristics of HLA
6.3 Molecular structure and distribution of HLA
6.4 Biological functions of MHC
6.5 Application of HLA in medicine
Leukocyte Differentiation antigens and Adhesion Molecules
课时目标：1. Master the concepts of LDA, CD and adhesion molecules;2. Be familiar with the functions of adhesion molecules; 3. Understand the classes of adhesion molecules, the clinical application of CD molecules, adhesion molecules and their McAbs.
7.1 Introduction of Membrane molecules of immune cells
7.2 Definition of LDA (leukocyte differentiation antigen) and CD molecules
7.3 Definition, classification and functions of CAM (cell adhesion molecules)
7.4 Clinical application of CD and CAM molecules
Innate Immunity
课时目标：1.master the definition of innate immunity2. Describe the composition of innate immunity3. Be familiar with action phase of innate immunity
13.1 Definition of innate immunity
13.2 Composition of innate immunity
13.3 Action phase of innate immunity
B lymphocytes
课时目标：1. Master surface molecules of B lymphocytes, the functions of B lymphocytes; 2. Be familiar the subsets of B cells.
8.1 B cell development
8.2 B cell membrane molecules
8.3 B cell subtypes and their functions
T lymphocytes
课时目标：1.Master the positive selection and negative selection of T cells during its development, master the surface markers of T lymphocytes and their functions;2. Master T lymphocyte subsets and their functions.
9.1 Development of T cell
9.2 Membrane molecules of T cell
9.3 Types and functions of T cell
Antigen presenting cell and Antigen Presentation
课时目标：1. Master the concept, classes and characteristics of antigen presentation cells;2. Master the processing of endogenous and exogenous antigens;3. Understand antigen processing and presentation by dendritic cells, macrophages and B cells.
10.1 Definition of APC
10.2 types and characteristics of APCs
10.3 Ag presentation Pathways
T cells mediated response（Cellular immunity ）
课时目标：1. Master T cells recognitions of antigens, signals for T cell activation, functions of effector T cells;2. Understand signals transduction, transcription factor activation and genes expression of T cells activation.
11.1 Definition of cellular immunity
11.2 Process of cellular immunity
B cells mediated response（Humoral immunity）
课时目标：1. Master the immune response of B cell to TD antigen, the rules of antibody production; 2. Be familiar with the immune response of B cells to TI antigens and mucosal immune response;
12.1 Definition of humoral immunity
12.2 Process of humoral immunity
12.3 B cell response to TD-Ag
12.4 B cell response to TI-Ag
12.5 Rules of Ab production
Immune tolerance
课时目标：1. Master the concept, development, and mechanisms of immune tolerance; 2. Understand immune tolerance and clinical medicine
14.1 Definition and features of immune tolerance
14.2 Mechanism of immune tolerances
14.3 Clinical application of immune tolerance
Hypersensitivity
课时目标：1. Master the concepts, mechanisms and common diseases of hypersensitivity, and the treatment of type I hypersensitivity;2. Be familiar with the common diseases of hypersensitivity.
15.1 Definition and classificationof hypersensitivity
15.2 of hypersensitivity
15.3 The diseases associated with hypersensitivity
15.4 The mechanism of hypersensitivity
Immunoprophylaxis
课时目标：1. Understand planned immunization,basic requirements and application of vaccines;2. Master artificial active immunization, artificial passive immunization and new vaccines.
16.1 planned immunization,basic requirements and application of vaccines
16.2 A rtificial active immunization, artificial passive immunization and new vaccines
Immune techniques
课时目标：1. Master the methods for detecting antigens, antibodies and lymphocytes; 2. Understand the principles of antigen-antibody reaction.
17.1 Methods for Detection of Ag and Ab
17.2 Application of immunologic tests
展开全部
预备知识
Immunology require the students have finished the courses in a number of topics, including biology, biochemistry , human anatomy，and histoembryology.
参考资料
(1) Janeways's Immunology, Kenneth Murphy, Paul Travers, Mark，8th edition,2012，Taylor & Francis publication.
(2) https://www.microbiologybook.org/book/immunol-sta.htm Immunology online website.
常见问题
1. What does Immunology do?Immunology is a broad field of biology involving the study of the immune system, also known as the body's defense system. Immunology deals with both normal and abnormal functioning of the immune system.
2. Is immunology easier to learn?
There is no faster or easier way to learn Immunology, NOT only Immunology but also other medical and biological sciences.
3.What will you learn from this Immunology course?
The basic knowledge gained from this course should make understand the fundamental ways the immune system protects self, and understand how deficiencies, excesses, or mistargeting of immune responses contribute to disease.
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