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Pathophysiology
第4次开课
开课时间: 2022年02月24日 ~ 2022年06月30日
学时安排: 3-5小时每周
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spContent=Why do patients get fever when having a cold? Why do severe trauma and infection cause shock? Why does cirrhosis cause delirium and coma? How can a never-ending heart fail? Do you want to explore the mysteries of diseases and find the key to cure them? Please join us in the MOOC of pathophysiology. With great enthusiasm, we will bring you for a roam in the knowledge sea of pathophysiology and to appreciate the endless charm of pathophysiology!
Why do patients get fever when having a cold? Why do severe trauma and infection cause shock? Why does cirrhosis cause delirium and coma? How can a never-ending heart fail? Do you want to explore the mysteries of diseases and find the key to cure them? Please join us in the MOOC of pathophysiology. With great enthusiasm, we will bring you for a roam in the knowledge sea of pathophysiology and to appreciate the endless charm of pathophysiology!
—— 课程团队
课程概述

Pathophysiology studies the rules and mechanisms of disease occurrence and development, and provides a theoretical basis for disease prevention and treatment. Pathophysiology is an important basic medical course which also has significant clinical attributes. It is a "bridge course" linking basic medical sciences and clinical medical sciences. After studying the knowledge of the structure, function and metabolism in normal human bodies, by learning pathophysiology, medical students can understand the functional and metabolic alterations in sick bodies, so as to lay a foundation for further study of clinical knowledge of various subjects. In this course we selected the most classic pathophysiology knowledge required by medical students, covering three major parts of content--overview of  pathophysiology, basic pathological processes, and systemic pathophysiology, a total of 14 chapters and 87 micro-lesson videos.


The course is designed based on the following principles:

1. To strengthen the combination with clinical knowledge. All micro-lesson videos in this course are guided by cases, which are echoed in the lecturing and unit testing. Some important principles of prevention and treatment are introduced in close combination with the pathogenesis.

2. To adhere to the "student-centered" teaching idea. Based on cases and questions, this course promotes step by step to inspire students to think. In addition, following each micro-lesson video, review questions are carefully designed to guide students’ autonomous learning. 

3. To persist the purpose of “enhance morality, foster talents”. Elements of medical moral education are carefully designed where is appropriate in each lecture, and professional pathophysiology teaching is organically combined with medical moral education.


Our teaching team has accumulated rich experience in the long-term practice of educational reform and curriculun construction, and formed distinct features. The team was awarded the National Excellent Course in 2005 and the National Excellent Resource-Sharing Course in 2016. We edited the national planning textbook Pathophysiology, and won the first prize of provincial teaching achievement twice. 


The course is mainly designed for undergraduate students in medical related majors. It also meets the needs for teachers, graduate students and clinical practitioners to improve their knowledge of pathophysiology.


Through studying the course, medical students will learn to correctly apply the knowledge and methods of pathophysiology to analyze the causes, mechanisms, functional and metabolic alterations, and understand the principles of prevention and treatment of diseases, and lay a foundation for their future study in clinical courses. 


授课目标

Through learning this course, the medical students can apply correctly the knowledge and methods of pathophysiology to analyze the causes and mechanisms and the metabolic and functional changes of diseases, and understand the principles of prevention and treatment of diseases.

课程大纲

1.Introduction of Pathophysiology

1.1 Introduction of Pathophysiology

2.Introduction to Disease

2.1 Health, subhealth and disease

2.2 General rules of disease occurence and development

2.3 Basic mechanism of disease occurence and development

2.4 Brain death

2.5 Disease models

Class discussion

Unit 1 test

3.Fluid and Electrolytes Imbalance

3.1 fluid and electrolytes introduction

3.2 hypertonic dehydration

3.3Hypotonicc dehydration

3.4 Edema and Abnormal Fluid Distribution between the Vascular and Interstitial Compartments

3.5 edema and retention of sodium and watar

3.6 hyperkalemia

3.7 hypokalemia

Class discussion

Unit 2 test

4. Acid-base balance and acid-base disturbance

4.1 Introduction

4.2 Regulation of acid-base balance

4.3 Parameters of acid-base balance

4.4 Basic ideas to analyze clinical cases with acid-base disturbance

4.5 Metabolic acidosis (1)

4.6 Metabolic acidosis (2)

4.7 Respiratory acidosis

4.8 Metabolic alkalosis

4.9 Respiratory Alkalosis

4.10 Mixed acid-base disturbance

Class discussion

Unit 3 test

5. Hypoxia

5.1 Introduction to Hypoxia

5.2 Hypoxic hypoxia

5.3 Hemic hypoxia

5.4 Circulatory hypoxia

5.5 Histogenous hypoxia

Class discussion

Unit 4 test

6. Fever

6.1 Fever-introduction

6.2 Pyrogenic activator

6.3 Endogenous pyrogen

6.4 Febrile ceiling

6.5 Periods of fever

6.6 Fever: Friend or Foe

Class discussion

Unit 5 test

7. Stress

7.1 Introduction of Stress

7.2 Neuroendocrine response

7.3 Acute phase response

7.4 Heat Shock Response

7.5 Stress Ulcer

7.6 PTSD

Unit 6 test

8.Ischemia-reperfusion injury

8.1 Introduction of ischemia-reperfusion injury

8.2 the role of reactive oxygen species

8.3 calcium overload

8.4 the role of leukocytes

8.5 ischemic preconditioning and ischemic post-conditioning

Class discussion

Unit 8 test

9.DIC

9.1 Disseminated Intravascular Coagulation

9.2 Pathogenesis of Disseminated Intravascular Coagulation

9.3 Alteration of Function and Metabolism during DIC

9.4 Principles of Diagnosis of DIC

Class discussion

Unit 9 test

10. Shock

10.1 Introduction of shock

10.2 Pathophysiology at the ischemic stage of microcirculation

10.3 Pathophysiology at the congestive stage of microcirculation

10.4 Pathophysiology at the failure stage of microcirculation(1)

10.5 Hemorrhagic shock

10.6 Infective shock

10.7 Anaphylactic shock

10.8 Cardiogenic shock

Class discussion

Unit 10 test

11. Heart failure

11.1 introduction of heart failure

11.2 compsensatory response

11.3 Ventricular remodeling

11.4 pathogenesis of heart failure

11.5 pathogensis of heart failure (II)

11.6 low cardiac output syndrome

11.7 venous congestion syndrome

Class discusion

Unit 11 test

12. Respiratory failure

12.1 Respiratory insufficiency-introduction

12.2 Restrictive hypoventilation

12.3 Obstructive hypoventilation

12.4 Diffusion impairment

12.5 Ventilation-perfusion imbalance

12.6 Pulmonary heart disease

12.7 Pulmonary encephalopathy

12.8 ARDS

Class discusion

Unit 12 test

13. Hepatic insufficiency

13.1 Hepatic Insufficiency--Introduction

13.2 Changes of Function and Metabolism in Hepatic Insufficiency

13.3 Hepatic Fibrosis

13.4 Hepatic Encephalopathy

13.5 Ammonia intoxication hypothesis

13.6 Gamma aminobutyric acid hypothesis

13.7 False neurotransmitter hypothesis and the amino acid imbalance hypothesis

13.8 Hepatorenal syndrome

Class discusion

Unit 13 test

14. Renal insufficiency

14.1 Introduction of renal insufficiency

14.2 Etiology and classification of acute renal failure

14.3 The pathogenesis of acute renal failure

14.4 Functional and metabolic changes in acute kidney failure

14.5 Chronic renal failure

14.6 Renal osteodystrophy

14.7 Uremia

Class discusion

Unit 14 test

展开全部
预备知识

Anthropotomy, Histology, Embryology, Physiology, Biochemistry, Microbiology, Immunology and other knowledge of basic medical sciences.

参考资料

1.《Textbook of Pathophysiology》,People`s Medical Publishing House,Chief editors: Jianzhi Wang, Huiming  Jin,2007.

2.《Textbook of Pathophysiology》,Science Publishing House,Chief editors of adaptation edition: Jianzhi Wang, Guoqiang Chen,2006.

3.《Pathophysiology》(4th edition) (in Chinese),Higher Education Press,Chief editor: Xianzhong Xiao,2018.


Central South University
1 位授课老师
Xianzhong Xiao

Xianzhong Xiao

Professor

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