spContent=Instrumental analysis is a subject that studies the analytical methods and related theories of chemical composition, content and structure by the signals of instrumentation. The course of "Instrumental Analysis" mainly focuses on the study of theoretical knowledge and application ability related to instrumental analysis in pharmacy. After years of continuous improvement and promotion, it was selected into the Provincial Excellent English Teaching Course Project for Foreign Students in Jiangsu Universities in 2017, and as one of the excellent representative courses for all English Teaching in Jiangsu Universities (top 20%), publicized and displayed on the foreign exchange website of Jiangsu Provincial Department of Education (https://english.jsjyt.edu.cn/2020-09/18/c_537598.htm) In 2020.
Instrumental analysis is a subject that studies the analytical methods and related theories of chemical composition, content and structure by the signals of instrumentation. The course of "Instrumental Analysis" mainly focuses on the study of theoretical knowledge and application ability related to instrumental analysis in pharmacy. After years of continuous improvement and promotion, it was selected into the Provincial Excellent English Teaching Course Project for Foreign Students in Jiangsu Universities in 2017, and as one of the excellent representative courses for all English Teaching in Jiangsu Universities (top 20%), publicized and displayed on the foreign exchange website of Jiangsu Provincial Department of Education (https://english.jsjyt.edu.cn/2020-09/18/c_537598.htm) In 2020.
—— 课程团队
课程概述
The Insrtumental Analysis course is to provide the good fundamental knowledge and skills of instrumental analysis for the international pharmacy students. Through the study of this course, students are required to master the basic knowledge, basic theory and basic operation technology of instrumental analysis, including spectroscopy, chromatography and electrochemistry, to understand some cutting-edge new technologies and methods, and to cultivate students' ability to analyze and solve practical problems in pharmaceutical analysis, which would be a solid foundation for their further study of pharmaceutical related professional courses and pharmaceutical research.
This course has a total of 34 teaching hours with the forms of lecture session and flip-classroom session in one academic semester. After all teachers’ lectures (30 teaching hours), an interesting online flipped classroom teaching in the form of "Small Group Discussion (SGD, 4 teaching hours) will be developed to guide students to analyze and solve some practical problems in pharmacy by using the knowledge of instrumental analysis under the guidance of instructors as well as the co-operation of students’ teams.
授课目标
Instrumental Analysis is the course of obtaining, processing, and communication information about the composition and structure of matter by instrumental analysis.
The aim of this course is to provide the knowledge of the composition of matters, analytical skills and related methodologies for modern chromatographic, spectral and electrochemical analysis in pharmaceutical separation and characterization, as well as provide an appropriate basis for the later study of pharmacy.
It is a core course of all pharmaceutical majors. On completion of this course, students should be able to:
- Master the basic principles of spectral analysis, including the UV-Vis, Fluorescence, and IR, and identify the unknown compounds based on the above spectral knowledge;
- Master the basic principles and calculation of chromatographic analysis, including GC, HPLC, and TLC;
- Master the basic principles and calculation of electrochemical analysis, including potentiometry and potentiometric titration;
- Understand other advanced modern technologies of instrumental analysis, such as Capillary Electrophoresis, Microchips, and Nano analysis;
- Solve some problems in pharmaceutical analysis based on the learning of above knowledge and skills of instrumental analysis.
课程大纲
Introduction to Spectroscopy and Molecular Spectroscopy
课时目标:To master the general terms related to spectroscopy;To be familiar with analytical determinations base on spectroscopy;To master the terms of molecular spectroscopy;Relate the theories to some practice.
1.1 The concept of spectroscopy
1.2 Properties of light
1.3 Quantitative analysis based on spectroscopy
1.4 The concept of molecular spectroscopy
Ultraviolet-Visible Spectroscopy
课时目标:To master the general terms related to UV-Vis Spectroscopy;To be familiar with the instrumentation for UV-Vis Spectroscopy;To be familiar with analytical determinations base on UV-Vis Spectroscopy
2.1 General principles of UV-Vis spectroscopy
2.2 Instrumentation for UV-Vis spectroscopy
2.3 Applications of UV-Vis spectroscopy
Molecular Luminescence Spectroscopy
课时目标:To master the general terms related to Luminescence Spectroscopy;To be familiar with the instrumentation for Luminescence Spectroscopy;To be familiar with analytical determinations base on Luminescence Spectroscopy
3.1 General Principles of Luminescence
3.2 Instrumentation for Luminescence Measurements
3.3 Applications of Molecular Luminescence
Molecular Infrared Spectroscopy
课时目标:To master the concepts and the relationship of Rotational & Vibrational energy levels; To master the difference of IR and UV-Vis spectra;To master the comparison of different vibrations;To master the interpretation of IR spectra;To be familiar with the IR instrument
4.1 Electronic energy levels
4.2 Principle of IR
4.3 Modes of vibration
4.4 Necessary conditions for the IR
4.5 Structure determination of compounds
4.6 IR instrument
Introduction to Chromatography
课时目标:To know the development of chromatography and the separation mechanisms of different types chromatography;To master the basic terms in chromatography and chromatogram;To master the calculation of separation efficiency and resolution etc;To know the application fields of chromatography.
5.1 General introduction to chromatography
5.2 Fundamentals of chromatography
5.3 Chromatogram and basic terms and parameters
5.4 Optimization of the column performance
5.5 Qualitative and quantitative analysis in chromatography
Gas Chromatography
课时目标:To master different detectors in GC and their applicable filed;To master the qualitative and quantitative methods in GC;To know the instrumentation and basic operation of GC;To know the selection of operational condition (column, stationary phase, flow rate, etc.) in GC
6.1 General introduction to gas chromatography
6.2 Columns and stationary phase
6.3 Instrumentations of gas chromatography
6.4 Selection of operating condition
6.5 Applications of gas chromatography
High Performance Liquid Chromatography
课时目标:To master the principle and features of HPLC; To master different types of HPLC and commonly used stationary phase and mobile phase;To know the operation of the HPLC;To know the instrumentations of HPLC;To know the applications of HPLC and HPLC-MS
7.1 General introduction to HPLC
7.2 Principles of HPLC
7.3 Instrumentations of HPLC
7.4 Selection of stationary phase and mobile phase
7.5 Introduction to HPLC-MS
7.6 Applications of HPLC
Planar Chromatography
课时目标:To know the history and applications of planar chromatography;To master the basic concept and operation techniques of planar chromatography;To master the key parameters in planar chromatography;To Master the stationary & mobile phase in TLC;To master the key notes for TLC technique
8.1 General introduction to planar chromatography
8.2 Retardation factor (Rf)
8.3 Stationary phase and mobile phase in TLC
8.4 Quantitative & qualitative measurement
Electrochemical Analysis and Potentiometry
课时目标:To master the introduction of Electrochemical analysis;To master the general principles of potentiometry;To be familiar with the Ion-Selective electrodes and related devices;To master what a potentiometric titration is; To master how to perform a potentiometric titration;To be familiar with the predicting and optimizing potentiometric titrations: procedures and examples
9.1 Introduction of Electrochemical analysis
9.2 General principles of potentiometry
9.3 Direct potentiometry
9.4 What is potentiometric titration?
9.5 Performing a potentiometric titration
9.6 Predicting and optimizing potentiometric titrations: procedures and examples.
Advanced Separation Technologies----Capillary Electrophoresis / Microchips / Nanotechnologies
课时目标:To master the principle of capillary electrophoresis;To know the development and application of microchip technique;To know the fundamentals of nanotechnology and the applications in analytical chemistry.
10.1 Capillary electrophoresis
10.2 Microchip technique
10.3 Nanotechnologies in analytical chemistry
Small Group Discussion
课时目标:Master the methods to solve the practical questions in instrumental analysis based on the above knowledge and technologies, as well as referring to the references and small group discussion are also encouraged.
Integrative competence of application of chromatography and molecular spectroscopy in pharmaceutical analysis
展开全部
预备知识
Inorganic Chemistry, Chemical Analysis
参考资料
Textbook
David S. Hage, James D. Carr. Analytical Chemistry and Quantitative Analysis. China Machine Press, 2012.
References
1. Skoog & West’s. Fundamentals of Analytical Chemistry (9th Ed.)
2. D.C. Harris. Quantitative Chemical Analysis (8th Ed.)
3. David Harvey. Analytical Chemistry 2.0 (2008,e-book)