spContent=Everyone live a life with the risk of disease. Drugs are always used for the diagnosis, prevention and treatment. Without having suitable dosage forms, raw drugs cannot take effect properly. A good dosage form can make raw drugs more safe, effective, and stable. We will introduce, analyse and discuss how to turn the raw drugs into safe and effective preparation products for clinical use with case studies in our pharmaceutics course.
Everyone live a life with the risk of disease. Drugs are always used for the diagnosis, prevention and treatment. Without having suitable dosage forms, raw drugs cannot take effect properly. A good dosage form can make raw drugs more safe, effective, and stable. We will introduce, analyse and discuss how to turn the raw drugs into safe and effective preparation products for clinical use with case studies in our pharmaceutics course.
—— 课程团队
课程概述
Pharmaceutics is interdisciplinary integrating knowledge and methods from medicine and pharmacy. It is a comprehensive discipline, covering the basic theory, formulation design, preparation process, quality control and clinical rational application of pharmaceutical preparations. The pharmaceutics course is indispensable for the education of all pharmacy students, and plays an utmostly important role in the cultivation of medical students.The fundamental aim of pharmaceutics is to enable effective drugs delivery to their target sites by means of various dosage forms, drug delivery systems, and drug delivery device. A better understanding of pharmaceutics would be greatly beneficial for the optimization of the dosage form design of drugs, improvement of the production technology, development of novel drug delivery system, and enhancement of the product quality. Pharmaceutics is also able to provide scientific foundation for the safe, rational, and effective application of drug products in clinics. At present, innovative researches on technologies, dosage forms, excipients, and equipment of pharmaceutics have been stepping forward to a new era of rapid development, aiming to serve for the needs of precise medicine. We believe that with the continuous development of pharmaceutics and its expanding associated science and technologies , more and more novel drug delivery methods will be established, which may result in more precise, intelligent, and efficient ways to facilitate human health in the future. Meanwhile, the healthy and vigorous development of pharmaceutics will further offer tremendous assistance for boosting the pharmacy research in China to a more advanced and leading position internationally.
授课目标
Upon completion of this course, you will have a good knowledge of the basic concepts and theories of pharmaceutical preparations; you will also acquire both the skills on preparing drugs into various of dosage forms and the ability on their quality control; you will be able to describe, discuss and demonstrate various pharmaceutical technologies and novel dosage forms, as well as the guidance for drug stability investigations and drug package selection.
课程大纲
Basic Theories of Pharmaceutics & Liquid Pharmaceutical Preparations (1)
课时目标：After finishing the learning of this week, attendents of the course are achieving the following goals: (1) will be able to describe what solubility and dissolution rate are; (2) will be able to compare and contrast the solubility and the dissolution rate; (3) will be able to select ways to determine solubility of a compound; (4) will be able to interpret factors involved in both the solubility and the dissolution rate of drugs; (5) will be able to solve issues on drugs with poor solubility or dissolution rate; (6) will be able to describe what surfactants are and how to classify them; (7) will be able to interpret both characterization and properties of surfactants; (8) will be able to explain applications of surfactants on pharmaceutics; (9) will be able to duplicate physicochemical properties of microparticle dispersion system; (10）will be able to explain size and distribution of particles, flocculation and deflocculation, and DLVO theory; (11) will be able to differentiate from Newton's fluid to non-Newton's fluid; (12) will be able to recognize rheologic properties of liquid and semisolid pharmaceutical dosage forms; (13) will be able to explain features and classification of liquid dosage forms; (14) will be able to describe both normal solvents and regular additives used for liquid dosage forms.
1.1 Solubility of Drugs
1.2 Dissolution Rate of Drugs
1.3 Surfactants: Definition, Characteristic and Classification
1.4 Surfactants: Properties and Applications
1.5 Microparticle Dispersion System
1.6 Rheology
2.1 Overview of Liquid Pharmaceutical Preparations
Liquid Pharmaceutical Preparations (2) & Aseptic Technologies
课时目标：After finishing the learning of this week,students will be able (1)to describe what solutions, polymeric solutions, suspensions, and emulsions are.(2)to distinguish dosage forms in dilisted in item 2 above.(3) to interpret manufacture process for dosage form listed in item 2 and to implement the most commonly used methods in making these dosage forms.(4) To interpret physical stabilities of suspensions and emulsions.(5)to explain provisions for quality assessment on dosage forms listed in item 2.(6) to describe theoretical and practical aspects of pharmaceutical waters preparation; (7)to describe theoretical and practical aspects of liquid filtration;(8) to describe properties and removal methods of pyrogen;(9)to describe theoretical and practical aspects of osmolarity regulation;(10) to describe theoretical and practical aspects of sterilization;(11) to describe methods of air purification.
2.2 Solutions and Polymeric Solutions
2.3 Suspensions
2.4 Emulsions
3.1 Pharmaceutical Waters
3.2 Liquid Filtration Technology
3.3 Pyrogen Removal Technique
3.4 Osmolarity Regulation Technology
3.5 Sterilization Technology
3.6 Air Purification Technology
Sterilized Preparations & Micromeritic
课时目标：After learning of week 3, students will be able to(1)examine the types of parenteral formulations; (2) provide an overview of the advantages and disadvantages of parenteral formulations;(3)describe the formulation considerations for parenteral formulations;(4) briefly describe manufacturing consideration of parenteral formulations;(5) evaluate the the quality of parenterals(6) describe the difference between small and large volume parenterals formulations that includes formulation and quality control;(7) describe the formulation and manufacturing considerations for sterile powder for injection.（8）describe the basic properties of powder and use the knowledge of powder science to solve the problems in solid preparation.
4.1 Parenterals
4.2 Formulation Development of Parenterals
4.3 Production of Parenterals
4.4 Quality Control of Parenterals
4.5 Examples of Injections
4.6 Large Volume Parenterals
4.7 Sterile Powder for Injection
5.1 Basic Properties of The Powder
5.2 Density and Porosity of The Powder
5.3 Flowability and Packability of The Powder
5.4 Moisture Absorption and Wetting of Powder
5.5 Adhesion, Cohesion and Compression of The Powder
Craft of Solid Preparations & Solid Preparations (1)
课时目标：After learning of this week, students will be able to(1) summarize the aim and significance of each unit operation of solid dosage forms; (2) design and prepare the formulation of solid dosage forms by using basic knowledge of each unit operation of solid dosage forms; (3) compare and contrast the characteristics of powder and granule;(4) describe the characteristics of the tablet and summarize the classification, characteristics and application of tablet excipients.
6.1 Unit Operation of Solid Preparation: Crushing
6.2 Unit Operation of Solid Preparation: Sieving
6.3 Unit Operation of Solid Preparation: Mixing and Kneading
6.4 Unit Operation of Solid Preparation: Granulation
6.5 Unit Operation of Solid Preparation——Drying
7.1 Powders
7.2 Granules
7.3 Tablet Overview
7.4 Commonly Used Excipients in Tablets (I)
7.5 Commonly Used Excipients in Tablets (II)
Solid Preparations (2) & Drug Delivery to the Skin (1)
课时目标：The objectives of this week are as follows (1) to categorize types of tablets preparation methods;(2) analyze and solve problems during tablet preparation; (3)to summarize the quality inspection items required for tablets;(4)to explain the advantages of coating (5) to compare films and paints for their formulation and application; (6) to describe the characteristics and influencing factors of transdermal drug delivery; (7) to demonstrate the formulation and preparation of ointments. What's more, when finishing the courses of this week, students will also be able (8) to describe what guttate pills is as well as its features; (9) to recognize excipients for guttate pills and to interpret the manufacturing process for the dosage form; (10) to recall the requirements of quality assessment on guttate pills.
7.6 Preparation of Tablets
7.7 Physical Properties and Influence Factors of The Tablets formation
7.8 Common Problems and Solutions of Tablets Preparation
7.9 Coating of Tablets
7.10 Quality Standards of Tablets
7.11 Examples of Tablets
7.12 Capsules
7.13 Guttate Pills
7.14 Films and Paints
8.1 Transdermal Drug Delivery
8.2 Ointments
展开全部
预备知识
1. Students should have the basis of medical knowledge on physiology, pathophysiology, pathology, physical chemistry, physics, organic chemistry, biochemistry, pharmaceutical chemistry, pharmacology, pharmaceutical analysis, etc.
2. Have a preliminary understanding of drug dosage forms and preparations, and have a strong interest.
参考资料
Basic Reference Book：
1. Aulton's Pharmaceutics (The Design and manufacture of medicines) (4th edition), CHURCHILL LIVINGSTONE ELSEVIER
Further Reference Books:
2. The Theory and Practice of Industrial Pharmacy (4th edition), CBS publishers & Distributors
3. Pharmaceutics-Dosage Form and Design (2th edition), Pharmaceutical Press
4. Ansel’s Pharmaceutical Dosage forms and Drug delivery systems (9th edition), LWW
常见问题
1. Learners should firstly log in the website: https://www.icourses.cn, and then register an account of icourses.
2. Please log in with the applied icourses account, enter the home page of icourses website, then click "MOOC of China University" and search " Pharmaceutics " to find the corresponding course icon. When we start the classes, you can use the learning page to learn " Pharmaceutics ".
3. Note: During the study of our course, you must use the same learning account to log in. Please don’t change the learning account, or your score will be affected.
4. Please fill in [name], [school], [gender] and other relevant contents on the webpage before the course, and fill in your personal information according to the requirements, so that the platform can export your grades after class, otherwise your study will be treated as no grades. Plagiarism and other dishonest academic phenomena are strictly prohibited in answering questions and examinations. Once found, they will be treated as no score.
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