Molecular Biology
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spContent=Genes are genetic material. Without heredity of genes, there would be no species. Without gene expression, there would be no growth of organisms. Without gene regulation, there would be no normal development of organisms. Would you like to know how genes are maintained, expressed and regulated? Would you like to understand the knowledge behind some useful technologies in biological research? Would you like to enhance your academic thinking and academic expression ability? Welcome to my course of Molecular Biology.
—— 课程团队
课程概述



Molecular Biology course explains the mechanisms of maintenance of the genome, expression of the genome and gene regulation at molecular level. The course also introduces the theoretical basis of some useful technologies applied in biological research.

 

Original Chinese version of this course has been online since 2015. Since then, it is highly praised by the learners. So far, there are more than 108,000 people have taken this course. In 2017, the course is awarded National Excellent Online Course on iCourse.

 

The major content of the course includes the structures of DNA, RNA and genome, DNA replication, RNA transcription, RNA splicing, protein translation, the genetic code, transcriptional regulation in prokaryotes and transcriptional regulation in eukaryotes. The content of this course are the basic knowledge required for biological research.

 

Currently, the teaching of this course is conducted as follows: first introduce the content in the courseware, then, go to the details of each point if necessary, and last, raise intriguing questions or ideas. If you have any advice on the teaching of this course, please let me know. I am willing to work with you and make this course better.


授课目标

1Help students master basic knowledge of molecular biology.

2Promote academic thinking.

3Enhance academic expression ability.

4Help students see how elaborate biological processes are.

5Stimulate interests in biology and biological research.


课程大纲
预备知识

Basic knowledge of biochemistry, genetics and cell biology.

证书要求

为积极响应国家低碳环保政策, 2021年秋季学期开始,中国大学MOOC平台将取消纸质版的认证证书,仅提供电子版的认证证书服务,证书申请方式和流程不变。

 

电子版认证证书支持查询验证,可通过扫描证书上的二维码进行有效性查询,或者访问 https://www.icourse163.org/verify,通过证书编号进行查询。学生可在“个人中心-证书-查看证书”页面自行下载、打印电子版认证证书。

 

完成课程教学内容学习和考核,成绩达到课程考核标准的学生(每门课程的考核标准不同,详见课程内的评分标准),具备申请认证证书资格,可在证书申请开放期间(以申请页面显示的时间为准),完成在线付费申请。

 

认证证书申请注意事项:

1. 根据国家相关法律法规要求,认证证书申请时要求进行实名认证,请保证所提交的实名认证信息真实完整有效。

2. 完成实名认证并支付后,系统将自动生成并发送电子版认证证书。电子版认证证书生成后不支持退费。


参考资料

Textbook

Molecular Biology of the Gene, Sixth Edition

Cold Spring Harbor Laboratory Press

James Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick

0-321-50781-9, 978-0-321-50781-5

 

References

Molecular Biology of the Gene, Seventh Edition

Cold Spring Harbor Laboratory Press

James Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick 

0-321-85149-8, 978-0-321-85149-9

 

Molecular Biology, Fifth Edition

McGraw-Hill Education

Robert F Weaver

0-073-52532-4, 978-0-073-52532-7

 

Meselson, M. S. & Stahl, F. W. The replication of DNA in Escherichia coli. Proc. Natl. Acad. Sci. 44:671-682 (1958).

 

Dintzis H.M. Assembly of the peptide chains of hemoglobin. Proc Natl Acad Sci USA. 47:247-261 (1961).

 

Dintzis H.M and Natughton M.A. Sequential biosynthesis of the peptide chains of hemoglobin. Proc Natl Acad Sci USA. 48:1822-30 (1962).

 

John Bishop, John Leahy and Richard Schweet. Formation of the peptide chain of hemoglobin. Proc Natl Acad Sci USA. 46:1030-1038 (1960).

 

Feng Song et al. Cryo-EM Study of the Chromatin Fiber Reveals a Double Helix Twisted by Tetranucleosomal Units. Science 344:376-380 (2014),

DOI: 10.1126/science.1251413.

 

Andrew Travers. The 30-nm Fiber Redux. Science 344:370-372 (2014),

DOI: 10.1126/science.1253852

 

Mo Xu, Chengzu Long, Xiuzhen Chen, Chang Huang, She Chen, Bing Zhu. Partitioning of Histone H3-H4 Tetramers during DNA replication-dependent chromatin assembly. Science 328:94-98, DOI: 10.1126/science.1178994.

 

Dominique Ray-Gallet and Geneviève Almouzni. Mixing or not mixing? Science 328: 56-57, DOI: 10.1126/science.1188653 (2010).

 

Lingner, Joachim, Julia Promisel Cooper, and Thomas Cech. Telomerase and DNA end replication: no longer a lagging strand problem? Science 269:1533-34 (1995).

 

Julien Soudet, Pascale Jolivet, and Maria Teresa Teixeira. Elucidation of the DNA end-replication problem in Saccharomyces cerevisiae. Molecular Cell 53:954–964 (2014).