细胞生物学是生命科学重要的基础学科之一，是分子生物学与个体生物学之间承上启下的学科。本课程主要是让学生了解细胞的基本结构及其功能，熟悉细胞生命活动的基本特点及其分子机制，并了解当前细胞生物学的发展动态和国际前沿知识。本课程为中英文双语教学，即授课用中文，而PPT，教材及考试都为英文。适合对生物感兴趣，或者立志将来从事生命科学研究的学生进行学习。
我们期待通过本课程的双语教学，使同学们能熟练掌握细胞生物学的基本概念和基本原理。熟悉相关领域内的关键词汇，提高同学们的阅读英文文献的能力，使同学们获得运用所学知识去分析科技文献中数据，跟踪本学科领域内的最新进展的能力。
Introduction of Molecular cell biology
The objectives and development of cell biology
Microscope and Cell theory
Major events in cell biology
Cell theory-test
Culturing and visualizing cells
Culturing and visualizing cells-test
Growing Cells in Culture
Monoclonal antibodies
Fluorescence Microscopy
Flow cytometry
Spinning Disk Confocal Microscopy
FRAP and FRET
RNA interference
Biomembrane Structure
The structrures of the plasmic membrane
The lipid bilayer: Composition and structural organization
Forms of lipid molecules exist in water
Lipids Movement in biomembrane
Structure of Membrane Proteins
Synthesis of Phospholipids and Intracellular Movement
Biomembrane Structure-test
Transmembrane transport of Ions and small molecules
Overview of transmembrane transport
Facilitated Transport of Glucose and Water
ATP –powered pumps
Na+/k+ pump
Ca2+ pump
K+ channel and the Resting membrane potencial
Cotransport by Symporters and Antiporters
Transcellular transport
Transmembrane transport of Ions and small molecules
Cellular Energetics
Electron Transport and Reactive Oxygen Species (ROS)
Overview of aerobic oxidation
Structure of Mitochondria
Mitochondrial Oxidation of Fatty Acids Generates ATP
The Electron Carriers and Electron Transport Chain
The Electron Transport and Generation of the Proton-Motive Force
Chemiosmotic theory and Endosymbiont hypothesis
Harnessing the Proton-Motive Force to synthesize ATP
Cellular Energetics
Moving Proteins into Membranes and Organelles
Moving Proteins into Membranes and Organelles
Targeting Proteins to and Across the ER Membrane
Insertion of single-pass Proteins into the ER
Insertion of Multipass Proteins into the ER
Protein Glycosylation and Folding in the ER
Formation of disulfide bonds in the ER
Protein Quality Control in the ER
Targeting of Proteins to Mitochondria
Targeting of Peroxisomal Proteins
Vesicular traffic,secretion and endocytosis
Molecular Mechanisms of Vesicle Budding and Fusion
Early Stages of the Secretory Pathway
Later Stages of the Secretory Pathway
Receptor-Mediated Endocytosis
Directing Membrane Proteins and Cytosolic Materials to the Lysosome
The structure and functions of Lysosomes
Vesicular traffic,secretion and endocytosis
Signal transduction and G protein-coupled receptors
Brief Introduction of Cell Communication
Signaling Molecules and Receptors
G Proteins and G Protein-coupled Receptors (GPCR)
GPCR Mediated Signaling pathways
Signal transduction
Signaling pathways that control gene activity
Outlines of Signaling pathways that control gene activity
Phosphoinositide Signaling Pathways
TGF-b Receptors and TGFb Signaling Pathways
Signaling Pathways controlled by Ubiquitination
The Ras/MAPK and JAK/STAT signaling pathway
Signaling pathways that control gene activity
Cell organization and movement I: Microfilaments
Actin Filaments
Dynamic Assembly of Actin Filaments
Actin-Based Cellular Structures
Myosins and Myosin-Powered Movements
Cell organization and movement I: Microfilament
Cell organization and movement II: Microtubules and intermediate filament
第一单元 Microtubule Structure and Organization
第二单元 Microtubule Dynamics
第三单元 Regulation of Microtubule Structure and Dynamics
第四单元 Kinesins & Dyneins: Microtubule-Based Motor Proteins
第五单元 Cilia & Flagella: Microtubule-Based Surface Structures
第六单元 Mitotic Spindle
第七单元 Intermediate Filaments
第八单元 Coordination and Cooperation Between Cytoskeletal Elements
Cell organization and movement II: Microtubules and intermediate filamen
Nucleus, chromatin and chromosomes
第一单元 Unit 1, Nuclear Envelope (NE), Nuclear Pore Complex (NPC) & Nuclear Transport
第二单元 Unit 2, Structural Organization of Eukaryotic Chromosomes
第三单元 Unit 3, Morphology and Functional Elements of Eukaryotic Chromosomes
第四单元 Unit 4, Nucleolus
Nucleus, chromatin and chromosomes 单元测验
The Eukaryotic Cell Cycle
The Eukaryotic Cell Cycle-test
第一单元 Unit 1, Overview of the Cell Cycle and Its Control
第二单元 Unit 2, Model Organisms and Methods to Study the Cell Cycle
第三单元 Unit 3, CDK and Its Discovery
第四单元 Unit 4, Regulation of CDK Activity
第五单元 Unit 5, Commitment to the Cell Cycle and DNA Replication
第六单元 Unit 6, Entry into Mitosis and Completion of Mitosis
第七单元 Unit 7, Surveillance Mechanisms in Cell Cycle Regulation
第八单元 Unit 8, Meiosis: A Special Type of Cell Division
Integrating cells into tissues
Ch20 Test -single answer choice
An Overview on Cell-Cell and Cell-Matrix Adhesion
Type of Cell Junctions and Anchoring Junctions
Tight junctions and Gap junctions
ECMs of The Basal Lamina
ECMs of Connective tissue
Stem cells, cell asymmetry and cell death
Early metazoan developmnt and embryonic stem cells
Stem Cells and Niches in Multicellular Organisms
Mechanisms of cell polarity and asymmetric cell division
Cell death and its regulation
Ch21 Test- single answer Choice
本课程的授课对象为大学二年级学生，前期课程应已修完生物化学、有机化学等基础学科。
本课程的学习过程包含：观看讲课视频、完成课后作业及讨论，参加期中，期末考试。
课程学习的最终成绩由一下几个部分组成：
(1) 单元测验成绩占40%
(2)期中考试成绩占30%
(3) 期末考试成绩占30%
在11月11日进行期中考试，12月23日进行期末考试，期中考试前的内容不再考察。
完成课程学习并考核合格(>=60分)的可获得合格证书，成绩优秀(>80分)的可获得优秀证书。
1. Molecular Cell Biology, 7th Edition, Harvey Lodish/Arnold Berk, etc., 2013, Macmillan Higher Education
2. Molecular Biology of The Cell, 6th Edition, Alberts B., et al., John Wilson/Tim Hunt, 2015, Garland Science
